PittsburghV1, Main, Exploration, bibRecord, 000D25

The impact of viral evolution and frequency of variant epitopes on primary and memory human immunodeficiency virus type 1-specific CD8⁺ T cell responses.

Identifieur interne : 000D25 ( Main/Exploration ); précédent : 000D24; suivant : 000D26

The impact of viral evolution and frequency of variant epitopes on primary and memory human immunodeficiency virus type 1-specific CD8⁺ T cell responses.

Auteurs : Nada M. Melhem [Liban] ; Kellie N. Smith [États-Unis] ; Xiao-Li Huang [États-Unis] ; Bonnie A. Colleton [États-Unis] ; Weimin Jiang [États-Unis] ; Robbie B. Mailliard [États-Unis] ; James I. Mullins [États-Unis] ; Charles R. Rinaldo [États-Unis]

Source :

Virology [ 1096-0341 ] ; 2014.

RBID : pubmed:24503065

Descripteurs français

KwdFr :
- Adulte, Agents antiVIH (usage thérapeutique), Antigènes d'histocompatibilité de classe I (génétique), Antigènes d'histocompatibilité de classe I (immunologie), Déterminants antigéniques des lymphocytes T (génétique), Déterminants antigéniques des lymphocytes T (immunologie), Humains, Infections à VIH (génétique), Infections à VIH (immunologie), Infections à VIH (traitement médicamenteux), Infections à VIH (virologie), Lymphocytes T (immunologie), Lymphocytes T (virologie), Lymphocytes T CD8+ (immunologie), Mâle, Protéines virales (génétique), Protéines virales (immunologie), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (immunologie), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (isolement et purification), Études de cohortes, Évolution moléculaire.
MESH :
- génétique : Antigènes d'histocompatibilité de classe I, Déterminants antigéniques des lymphocytes T, Infections à VIH, Protéines virales, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- immunologie : Antigènes d'histocompatibilité de classe I, Déterminants antigéniques des lymphocytes T, Infections à VIH, Lymphocytes T, Lymphocytes T CD8+, Protéines virales, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- isolement et purification : VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- traitement médicamenteux : Infections à VIH.
- usage thérapeutique : Agents antiVIH.
- virologie : Infections à VIH, Lymphocytes T.
- Adulte, Humains, Mâle, Études de cohortes, Évolution moléculaire.

English descriptors

KwdEn :
- Adult, Anti-HIV Agents (therapeutic use), CD8-Positive T-Lymphocytes (immunology), Cohort Studies, Epitopes, T-Lymphocyte (genetics), Epitopes, T-Lymphocyte (immunology), Evolution, Molecular, HIV Infections (drug therapy), HIV Infections (genetics), HIV Infections (immunology), HIV Infections (virology), HIV-1 (genetics), HIV-1 (immunology), HIV-1 (isolation & purification), Histocompatibility Antigens Class I (genetics), Histocompatibility Antigens Class I (immunology), Humans, Male, T-Lymphocytes (immunology), T-Lymphocytes (virology), Viral Proteins (genetics), Viral Proteins (immunology).
MESH :
- chemical , genetics : Epitopes, T-Lymphocyte, Histocompatibility Antigens Class I, Viral Proteins.
- chemical , immunology : Epitopes, T-Lymphocyte, Histocompatibility Antigens Class I, Viral Proteins.
- chemical , therapeutic use : Anti-HIV Agents.
- drug therapy : HIV Infections.
- genetics : HIV Infections, HIV-1.
- immunology : CD8-Positive T-Lymphocytes, HIV Infections, HIV-1, T-Lymphocytes.
- isolation & purification : HIV-1.
- virology : HIV Infections, T-Lymphocytes.
- Adult, Cohort Studies, Evolution, Molecular, Humans, Male.

Abstract

It is unclear if HIV-1 variants lose the ability to prime naïve CD8(+) cytotoxic T lymphocytes (CTL) during progressive, untreated infection. We conducted a comprehensive longitudinal analysis of viral evolution and its impact on primary and memory CD8(+) T cell responses pre-seroconversion (SC), post-SC, and during combination antiretroviral therapy (cART). Memory T cell responses targeting autologous virus variants reached a nadir by 8 years post-SC with development of AIDS, followed by a transient enhancement of anti-HIV-1 CTL responses upon initiation of cART. We show broad and high magnitude primary T cell responses to late variants in pre-SC T cells, comparable to primary anti-HIV-1 responses induced in T cells from uninfected persons. Despite evolutionary changes, CD8(+) T cells could still be primed to HIV-1 variants. Hence, vaccination against late, mutated epitopes could be successful in enhancing primary reactivity of T cells for control of the residual reservoir of HIV-1 during cART.

DOI: 10.1016/j.virol.2013.10.015
PubMed: 24503065

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The impact of viral evolution and frequency of variant epitopes on primary and memory human immunodeficiency virus type 1-specific CD8⁺ T cell responses.</title>
<author><name sortKey="Melhem, Nada M" sort="Melhem, Nada M" uniqKey="Melhem N" first="Nada M" last="Melhem">Nada M. Melhem</name>
<affiliation wicri:level="1"><nlm:affiliation>American University of Beirut, Faculty of Health Sciences, Medical Laboratory Sciences Program, 11-0236 Riad El Solh, 1107-2020 Beirut, Lebanon.</nlm:affiliation>
<country xml:lang="fr">Liban</country>
<wicri:regionArea>American University of Beirut, Faculty of Health Sciences, Medical Laboratory Sciences Program, 11-0236 Riad El Solh, 1107-2020 Beirut</wicri:regionArea>
<wicri:noRegion>1107-2020 Beirut</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Smith, Kellie N" sort="Smith, Kellie N" uniqKey="Smith K" first="Kellie N" last="Smith">Kellie N. Smith</name>
<affiliation wicri:level="4"><nlm:affiliation>University of Pittsburgh, School of Medicine, Department of Microbiology and Molecular Genetics, Pittsburgh, PA 15213, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pittsburgh, School of Medicine, Department of Microbiology and Molecular Genetics, Pittsburgh, PA 15213</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
<settlement type="city">Pittsburgh</settlement>
</placeName>
<orgName type="university">Université de Pittsburgh</orgName>
</affiliation>
</author>
<author><name sortKey="Huang, Xiao Li" sort="Huang, Xiao Li" uniqKey="Huang X" first="Xiao-Li" last="Huang">Xiao-Li Huang</name>
<affiliation wicri:level="4"><nlm:affiliation>University of Pittsburgh, Graduate School of Public Health, Department of Infectious Diseases and Microbiology, Pittsburgh, PA, 15261, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pittsburgh, Graduate School of Public Health, Department of Infectious Diseases and Microbiology, Pittsburgh, PA, 15261</wicri:regionArea>
<orgName type="university">Université de Pittsburgh</orgName>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Colleton, Bonnie A" sort="Colleton, Bonnie A" uniqKey="Colleton B" first="Bonnie A" last="Colleton">Bonnie A. Colleton</name>
<affiliation wicri:level="4"><nlm:affiliation>Pennsylvania State University, M.S. Hershey Medical Center College of Medicine, Department of Public Health Sciences, Hershey, PA 17033, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Pennsylvania State University, M.S. Hershey Medical Center College of Medicine, Department of Public Health Sciences, Hershey, PA 17033</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
<settlement type="city">University Park (Pennsylvanie)</settlement>
</placeName>
<orgName type="university">Université d'État de Pennsylvanie</orgName>
</affiliation>
</author>
<author><name sortKey="Jiang, Weimin" sort="Jiang, Weimin" uniqKey="Jiang W" first="Weimin" last="Jiang">Weimin Jiang</name>
<affiliation wicri:level="4"><nlm:affiliation>University of Pittsburgh, Graduate School of Public Health, Department of Infectious Diseases and Microbiology, Pittsburgh, PA, 15261, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pittsburgh, Graduate School of Public Health, Department of Infectious Diseases and Microbiology, Pittsburgh, PA, 15261</wicri:regionArea>
<orgName type="university">Université de Pittsburgh</orgName>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mailliard, Robbie B" sort="Mailliard, Robbie B" uniqKey="Mailliard R" first="Robbie B" last="Mailliard">Robbie B. Mailliard</name>
<affiliation wicri:level="4"><nlm:affiliation>University of Pittsburgh, Graduate School of Public Health, Department of Infectious Diseases and Microbiology, Pittsburgh, PA, 15261, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pittsburgh, Graduate School of Public Health, Department of Infectious Diseases and Microbiology, Pittsburgh, PA, 15261</wicri:regionArea>
<orgName type="university">Université de Pittsburgh</orgName>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mullins, James I" sort="Mullins, James I" uniqKey="Mullins J" first="James I" last="Mullins">James I. Mullins</name>
<affiliation wicri:level="4"><nlm:affiliation>University of Washington, School of Medicine, Department of Microbiology, Seattle, WA 98195-8070, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Washington, School of Medicine, Department of Microbiology, Seattle, WA 98195-8070</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Rinaldo, Charles R" sort="Rinaldo, Charles R" uniqKey="Rinaldo C" first="Charles R" last="Rinaldo">Charles R. Rinaldo</name>
<affiliation wicri:level="4"><nlm:affiliation>University of Pittsburgh, Graduate School of Public Health, Department of Infectious Diseases and Microbiology, Pittsburgh, PA, 15261, USA. Electronic address: rinaldo@pitt.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pittsburgh, Graduate School of Public Health, Department of Infectious Diseases and Microbiology, Pittsburgh, PA, 15261</wicri:regionArea>
<orgName type="university">Université de Pittsburgh</orgName>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2014">2014</date>
<idno type="RBID">pubmed:24503065</idno>
<idno type="pmid">24503065</idno>
<idno type="doi">10.1016/j.virol.2013.10.015</idno>
<idno type="wicri:Area/PubMed/Corpus">003C50</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003C50</idno>
<idno type="wicri:Area/PubMed/Curation">003C23</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003C23</idno>
<idno type="wicri:Area/PubMed/Checkpoint">003C23</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003C23</idno>
<idno type="wicri:Area/Ncbi/Merge">001006</idno>
<idno type="wicri:Area/Ncbi/Curation">001006</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001006</idno>
<idno type="wicri:Area/Main/Merge">000D40</idno>
<idno type="wicri:Area/Main/Curation">000D25</idno>
<idno type="wicri:Area/Main/Exploration">000D25</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">The impact of viral evolution and frequency of variant epitopes on primary and memory human immunodeficiency virus type 1-specific CD8⁺ T cell responses.</title>
<author><name sortKey="Melhem, Nada M" sort="Melhem, Nada M" uniqKey="Melhem N" first="Nada M" last="Melhem">Nada M. Melhem</name>
<affiliation wicri:level="1"><nlm:affiliation>American University of Beirut, Faculty of Health Sciences, Medical Laboratory Sciences Program, 11-0236 Riad El Solh, 1107-2020 Beirut, Lebanon.</nlm:affiliation>
<country xml:lang="fr">Liban</country>
<wicri:regionArea>American University of Beirut, Faculty of Health Sciences, Medical Laboratory Sciences Program, 11-0236 Riad El Solh, 1107-2020 Beirut</wicri:regionArea>
<wicri:noRegion>1107-2020 Beirut</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Smith, Kellie N" sort="Smith, Kellie N" uniqKey="Smith K" first="Kellie N" last="Smith">Kellie N. Smith</name>
<affiliation wicri:level="4"><nlm:affiliation>University of Pittsburgh, School of Medicine, Department of Microbiology and Molecular Genetics, Pittsburgh, PA 15213, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pittsburgh, School of Medicine, Department of Microbiology and Molecular Genetics, Pittsburgh, PA 15213</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
<settlement type="city">Pittsburgh</settlement>
</placeName>
<orgName type="university">Université de Pittsburgh</orgName>
</affiliation>
</author>
<author><name sortKey="Huang, Xiao Li" sort="Huang, Xiao Li" uniqKey="Huang X" first="Xiao-Li" last="Huang">Xiao-Li Huang</name>
<affiliation wicri:level="4"><nlm:affiliation>University of Pittsburgh, Graduate School of Public Health, Department of Infectious Diseases and Microbiology, Pittsburgh, PA, 15261, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pittsburgh, Graduate School of Public Health, Department of Infectious Diseases and Microbiology, Pittsburgh, PA, 15261</wicri:regionArea>
<orgName type="university">Université de Pittsburgh</orgName>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Colleton, Bonnie A" sort="Colleton, Bonnie A" uniqKey="Colleton B" first="Bonnie A" last="Colleton">Bonnie A. Colleton</name>
<affiliation wicri:level="4"><nlm:affiliation>Pennsylvania State University, M.S. Hershey Medical Center College of Medicine, Department of Public Health Sciences, Hershey, PA 17033, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Pennsylvania State University, M.S. Hershey Medical Center College of Medicine, Department of Public Health Sciences, Hershey, PA 17033</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
<settlement type="city">University Park (Pennsylvanie)</settlement>
</placeName>
<orgName type="university">Université d'État de Pennsylvanie</orgName>
</affiliation>
</author>
<author><name sortKey="Jiang, Weimin" sort="Jiang, Weimin" uniqKey="Jiang W" first="Weimin" last="Jiang">Weimin Jiang</name>
<affiliation wicri:level="4"><nlm:affiliation>University of Pittsburgh, Graduate School of Public Health, Department of Infectious Diseases and Microbiology, Pittsburgh, PA, 15261, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pittsburgh, Graduate School of Public Health, Department of Infectious Diseases and Microbiology, Pittsburgh, PA, 15261</wicri:regionArea>
<orgName type="university">Université de Pittsburgh</orgName>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mailliard, Robbie B" sort="Mailliard, Robbie B" uniqKey="Mailliard R" first="Robbie B" last="Mailliard">Robbie B. Mailliard</name>
<affiliation wicri:level="4"><nlm:affiliation>University of Pittsburgh, Graduate School of Public Health, Department of Infectious Diseases and Microbiology, Pittsburgh, PA, 15261, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pittsburgh, Graduate School of Public Health, Department of Infectious Diseases and Microbiology, Pittsburgh, PA, 15261</wicri:regionArea>
<orgName type="university">Université de Pittsburgh</orgName>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mullins, James I" sort="Mullins, James I" uniqKey="Mullins J" first="James I" last="Mullins">James I. Mullins</name>
<affiliation wicri:level="4"><nlm:affiliation>University of Washington, School of Medicine, Department of Microbiology, Seattle, WA 98195-8070, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Washington, School of Medicine, Department of Microbiology, Seattle, WA 98195-8070</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Rinaldo, Charles R" sort="Rinaldo, Charles R" uniqKey="Rinaldo C" first="Charles R" last="Rinaldo">Charles R. Rinaldo</name>
<affiliation wicri:level="4"><nlm:affiliation>University of Pittsburgh, Graduate School of Public Health, Department of Infectious Diseases and Microbiology, Pittsburgh, PA, 15261, USA. Electronic address: rinaldo@pitt.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pittsburgh, Graduate School of Public Health, Department of Infectious Diseases and Microbiology, Pittsburgh, PA, 15261</wicri:regionArea>
<orgName type="university">Université de Pittsburgh</orgName>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Virology</title>
<idno type="eISSN">1096-0341</idno>
<imprint><date when="2014" type="published">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Anti-HIV Agents (therapeutic use)</term>
<term>CD8-Positive T-Lymphocytes (immunology)</term>
<term>Cohort Studies</term>
<term>Epitopes, T-Lymphocyte (genetics)</term>
<term>Epitopes, T-Lymphocyte (immunology)</term>
<term>Evolution, Molecular</term>
<term>HIV Infections (drug therapy)</term>
<term>HIV Infections (genetics)</term>
<term>HIV Infections (immunology)</term>
<term>HIV Infections (virology)</term>
<term>HIV-1 (genetics)</term>
<term>HIV-1 (immunology)</term>
<term>HIV-1 (isolation & purification)</term>
<term>Histocompatibility Antigens Class I (genetics)</term>
<term>Histocompatibility Antigens Class I (immunology)</term>
<term>Humans</term>
<term>Male</term>
<term>T-Lymphocytes (immunology)</term>
<term>T-Lymphocytes (virology)</term>
<term>Viral Proteins (genetics)</term>
<term>Viral Proteins (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Agents antiVIH (usage thérapeutique)</term>
<term>Antigènes d'histocompatibilité de classe I (génétique)</term>
<term>Antigènes d'histocompatibilité de classe I (immunologie)</term>
<term>Déterminants antigéniques des lymphocytes T (génétique)</term>
<term>Déterminants antigéniques des lymphocytes T (immunologie)</term>
<term>Humains</term>
<term>Infections à VIH (génétique)</term>
<term>Infections à VIH (immunologie)</term>
<term>Infections à VIH (traitement médicamenteux)</term>
<term>Infections à VIH (virologie)</term>
<term>Lymphocytes T (immunologie)</term>
<term>Lymphocytes T (virologie)</term>
<term>Lymphocytes T CD8+ (immunologie)</term>
<term>Mâle</term>
<term>Protéines virales (génétique)</term>
<term>Protéines virales (immunologie)</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique)</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (immunologie)</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (isolement et purification)</term>
<term>Études de cohortes</term>
<term>Évolution moléculaire</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Epitopes, T-Lymphocyte</term>
<term>Histocompatibility Antigens Class I</term>
<term>Viral Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Epitopes, T-Lymphocyte</term>
<term>Histocompatibility Antigens Class I</term>
<term>Viral Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-HIV Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>HIV Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>HIV Infections</term>
<term>HIV-1</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes d'histocompatibilité de classe I</term>
<term>Déterminants antigéniques des lymphocytes T</term>
<term>Infections à VIH</term>
<term>Protéines virales</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes d'histocompatibilité de classe I</term>
<term>Déterminants antigéniques des lymphocytes T</term>
<term>Infections à VIH</term>
<term>Lymphocytes T</term>
<term>Lymphocytes T CD8+</term>
<term>Protéines virales</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>CD8-Positive T-Lymphocytes</term>
<term>HIV Infections</term>
<term>HIV-1</term>
<term>T-Lymphocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>HIV-1</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à VIH</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Agents antiVIH</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à VIH</term>
<term>Lymphocytes T</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>HIV Infections</term>
<term>T-Lymphocytes</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Cohort Studies</term>
<term>Evolution, Molecular</term>
<term>Humans</term>
<term>Male</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Humains</term>
<term>Mâle</term>
<term>Études de cohortes</term>
<term>Évolution moléculaire</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">It is unclear if HIV-1 variants lose the ability to prime naïve CD8(+) cytotoxic T lymphocytes (CTL) during progressive, untreated infection. We conducted a comprehensive longitudinal analysis of viral evolution and its impact on primary and memory CD8(+) T cell responses pre-seroconversion (SC), post-SC, and during combination antiretroviral therapy (cART). Memory T cell responses targeting autologous virus variants reached a nadir by 8 years post-SC with development of AIDS, followed by a transient enhancement of anti-HIV-1 CTL responses upon initiation of cART. We show broad and high magnitude primary T cell responses to late variants in pre-SC T cells, comparable to primary anti-HIV-1 responses induced in T cells from uninfected persons. Despite evolutionary changes, CD8(+) T cells could still be primed to HIV-1 variants. Hence, vaccination against late, mutated epitopes could be successful in enhancing primary reactivity of T cells for control of the residual reservoir of HIV-1 during cART.</div>
</front>
</TEI>
<affiliations><list><country><li>Liban</li>
<li>États-Unis</li>
</country>
<region><li>Pennsylvanie</li>
<li>Washington (État)</li>
</region>
<settlement><li>Pittsburgh</li>
<li>Seattle</li>
<li>University Park (Pennsylvanie)</li>
</settlement>
<orgName><li>Université d'État de Pennsylvanie</li>
<li>Université de Pittsburgh</li>
<li>Université de Washington</li>
</orgName>
</list>
<tree><country name="Liban"><noRegion><name sortKey="Melhem, Nada M" sort="Melhem, Nada M" uniqKey="Melhem N" first="Nada M" last="Melhem">Nada M. Melhem</name>
</noRegion>
</country>
<country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Smith, Kellie N" sort="Smith, Kellie N" uniqKey="Smith K" first="Kellie N" last="Smith">Kellie N. Smith</name>
</region>
<name sortKey="Colleton, Bonnie A" sort="Colleton, Bonnie A" uniqKey="Colleton B" first="Bonnie A" last="Colleton">Bonnie A. Colleton</name>
<name sortKey="Huang, Xiao Li" sort="Huang, Xiao Li" uniqKey="Huang X" first="Xiao-Li" last="Huang">Xiao-Li Huang</name>
<name sortKey="Jiang, Weimin" sort="Jiang, Weimin" uniqKey="Jiang W" first="Weimin" last="Jiang">Weimin Jiang</name>
<name sortKey="Mailliard, Robbie B" sort="Mailliard, Robbie B" uniqKey="Mailliard R" first="Robbie B" last="Mailliard">Robbie B. Mailliard</name>
<name sortKey="Mullins, James I" sort="Mullins, James I" uniqKey="Mullins J" first="James I" last="Mullins">James I. Mullins</name>
<name sortKey="Rinaldo, Charles R" sort="Rinaldo, Charles R" uniqKey="Rinaldo C" first="Charles R" last="Rinaldo">Charles R. Rinaldo</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Amérique/explor/PittsburghV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000D25 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000D25 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Amérique
   |area=    PittsburghV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:24503065
   |texte=   The impact of viral evolution and frequency of variant epitopes on primary and memory human immunodeficiency virus type 1-specific CD8⁺ T cell responses.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:24503065" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a PittsburghV1

This area was generated with Dilib version V0.6.38.
Data generation: Fri Jun 18 17:37:45 2021. Site generation: Fri Jun 18 18:15:47 2021

Serveur d'exploration sur Pittsburgh

The impact of viral evolution and frequency of variant epitopes on primary and memory human immunodeficiency virus type 1-specific CD8⁺ T cell responses.

The impact of viral evolution and frequency of variant epitopes on primary and memory human immunodeficiency virus type 1-specific CD8⁺ T cell responses.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur Pittsburgh
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.